Publications

Signal Transduction Assays
Related ECIS Publications

Qiao, J., Huang, F., Naikawadi, R.P., Kim, K.S., Said, T., Hazel Lum, H., "Lysophosphatidylcholine Impairs Endothelial Barrier Function through the G Protein-Coupled Receptor, GPR4." AJP Lung Cell Mol Physiol 0: 00508.2005v1 (2006).

Meyer, M.C., McHowat, J., "Calcium-Independent Phospholipase A2-Catalyzed Plasmalogen Hydrolysis in Hypoxic Human Coronary Artery Endothelial Cells", [PDF] Am J Physiol Cell Physiol (2006).

ten Klooster, J. P., Jeffer, Z.M., Chernoff, J., Hordijk, P.L. "Targeting and activation of Rac1 are mediated by the exchange factor B-Pix." J. Cell Biology. 172 (5): 759-769 (2006).

Ren, J., Xiao, Y., Singh, L.S., Zhao, X., Zhao, Z., Feng, L., Rose, T.M., Prestwich, G.D., Xu, Y.,"Lysophosphatidic Acid Is Constitutively Produced by Human Peritoneal Mesothelial Cells and Enhances Adhesion, Migration, and Invasion of Ovarian Cancer Cells." [PDF] Cancer Res 2006; 66: (6) (2006).

Meyer, M.C., Kell, P.J., Creer, M.H., McHowat, J., "Calcium-independent phospholipase A2 is regulated by a novel protein kinase C in human coronary artery endothelial cells", Am J Physiol Cell Physiol 288: C475-C482, (2005).

Becker, P.M., Waltenberger, J., Yachechko, R., Mirzapoiazova, T., Sham, J.S.K., Lee, C.G., Elias, J.A., Verin, A.D., "Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability." Circulation Research, 96:1257-1265, (2005).

Charrier, L., Yan, Y., Driss, A., Laboisse, C.L., Sitaraman, S.V. and Merlin, D.,"ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers." [PDF] AJP Gastrointest Liver Physiol. 288:346-353, (2005).

Weidenfeller, C., Schrot, S., Zozulya, A., Galla, H.J.,"Murine brain capillary endothelial cells exhibit improved barrier properties under the influence of hydrocortisone." [PDF] Brain Res. 1053(1-2):162-74 (2005).

McLaughlin, J.N., Shen, L., Holinstat, M., Brooks, J.D., DiBenedetto, E., Hamm, H.E., "Functional Selectivity of G Protein Signaling by Agonist Peptides and Thrombin for the Protease-activated Receptor-1." J. Biol. Chem. 280(26): 25048-25059 (2005).

McLaughlin, J.N., Mazzoni, M.R., Cleator, J.H., Earls, L., Perdigoto, A.L., Brooks, J.D., Muldowney, J.A.S., Vaughan, D.E., Hamm, H.E., "Thrombin Modulates the Expression of a Set of Genes Including Thrombospondin-1 in Human Microvascular Endothelial Cells." J. Biol. Chem. 280(23): 22172-22180 (2005).

Wu, M.H. "Endothelial focal adhesions and barrier function." J. Physiology. 569(2): 359 (2005).

Huang, F.,Subbaiah, P., Holian, O.,Zhang, J.,Johnson, A.,Gertzberg, N.,Lum, H., "Lysophosphatidylcholine Increases Endothelial Permeability: Role of PKC and RhoA Cross-talk" Am J Physiol Lung Cell Mol Physiol 289: L176-L185, (2005).

Kilani, M.M., Mohammed, K.A., Nasreen, N., Tepper, R.S., Antony, V.B., "RSV causes HIF-1alpha stabilization via NO release in primary bronchial epithelial cells." Inflammation. 28(5):245-5, (2004).

Zeng, W., Matter, W.F., Yan, S.B., Um, S.L., Vlahos, C.J., Liu, L., "Effect of drotrecogin alfa (activated) on human endothelial cell permeability and Rho kinase signaling." Critical Care Medicine. 32(5): S302-S308 (2004).

Regard, J.B., Scheek, S., Borbiev, T., Lanahan, A.A., Schneider, A., Demetriades, A.M., Hiemisch, H., Barnes, C.A., Verin, A.D., Worley, P.F., "Verge: A Novel Vascular Early Reponse Gene." The Journal of Neuroscience. 24(16):4092-4103 (2004)

Clements, R., Minnear, R., Singer, H., Keller, R., Vincent, P., "RhoA and Rho-kinase dependent and independent signals mediate TGF--induced pulmonary endothelial cytoskeletal reorganization and permeability" Am J Physiol Lung Cell Mol Physiol 288: L294-L306, (2004).

Ramirez-Icaza G, Mohammed KA, Nasreen N, Van Horn RD, Hardwick JA, Sanders KL, Tian J, Ramirez-Icaza C, Johnson MT, Antony VB. "Th2 cytokines IL-4 and IL-13 downregulate paxillin expression in bronchial airway epithelial cells." J Clin Immunol. 24(4):426-34 (2004).

Wang Q, Turlington A, Heo S, Blanco A, Tian J, Xie Z, Yan B, Wan Y., "Extracellular matrix activity and caveolae events contribute to cell surface receptor activation that leads to MAP kinase activation in response to UV irradiation in cultured human keratinocytes." Int J Mol Med. Apr;15(4):633-40 (2005)

De Blasio, B.F., Rottingen, J.A., Sand, K.L., Giaever, I., Iversen, J.G. "Global synchronous oscillations in cytosolic calcium and adherence in bradykinin- stimulated Madin-Darby canine kidney cells." Acta Physiol Scand 180: 335-346 (2004)

Kim, Yuri V., Di Cello, Francescopaolo, Hillaire, Coryse S., Kim, Kwang Sik. "Differential Ca+ signaling by thrombin and protease-activated receptor-1-activating peptide in human brain microvascular endothelial cells." [PDF] American Journal of Physiology-Cell Physiology, 286: C31-C42 (2004).

Hug, T.S. "Biophysical methods for monitoring cell-substrate interactions in drug discovery." Assay Drug Dev Technol. 1(3):479-88. Review (2003).

Schmidt, M.H., Chen, B., Randazzo, L.M., Bogler, O. "SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion." J Cell Sci. 116(Pt 14):2845-55 (2003).

Sawhney RS, Sharma B, Humphrey LE, Brattain MG. "Integrin alpha2 and extracellular signal-regulated kinase are functionally linked in highly malignant autocrine transforming growth factor-alpha-driven colon cancer cells." J Biol Chem. 278(22):19861-9 (2003).

reAas, V., Torbla, S., Andersen, M.H., Jensen, J., Rustan, A.C. "Electrical stimulation improves insulin responses in a human skeletal muscle cell model of hyperglycemia." [PDF] Ann N Y Acad Sci. 967:506-15 (2002).

Hillebrandt, H. Abdelghani, A. Abdelghani-Jacquin, C. Aepfelbacher, M. Sackmann, "Electrical and optical characterization of thrombin-induced permeability of cultured endothelial cell monolayers on semiconductor electrode arrays", Applied Physics A-Material Science & Processing, 73 (5): 539-546, 2001.

Tiruppathi, C., W. Yan, R. Sandoval., T. Naqvi., A. N. Pronin., J.L. Benovic, and A. B. Malik. "G protein-coupled receptor kinase-5 regulates Thrombin-Activated signaling in endothelial cells", Proc. Natl. Acad. Sci. USA. 97:7440-7445, 2000.

Patterson, C.E., Lum, H. Schaphorst, K.L., Verin, A.D., and Garcia, J.G.N. "Regulation of Endothelial Barrier Function by the cAMP-dependent Protein Kinase", Endotherlium, 7(4): 287-308, 2000

Wegener, J., Zink, S., Rosen, P., GAlla, H., "Use of Electrochemical Impedance measurements to monitor B-adrenergic stimulation of bovine aortic endothelial cells." [PDF] Eur J Physiol 437: 925-934, 1999.

Reddy, L., Wang, H.S., Keese, C.R., Giaever, I., Smith, T.J., "Assessment of rapid morphological changes associated with elevated cAMP levels in human orbital fibroblasts", Experimental Cell Research, 245 (2): 360-367 (1998).