ECIS School Graduates (March 2017)
From left to right: Ying Lui - University of Pennsylvania, Koreana Pak - University of Pennsylvania, Nektarios Barabutis - Old Dominion University, Raji Rajesh - Lenin-University of Tennessee Health Science Centre, Bethany Young - Virginia Commonwealth University, Gaelle Mercenne - Recursion Pharmaceuticals
Nektarios Barabutis, M.Sc., Ph.D
Frank Reidy Research Center for Bioelectrics, Old Dominion University
Research Focus: Dr. Nektarios Barabutis is interested on the mechanisms which govern the regulation of vascular permeability in lung tissues. He has recently introduced the protective role of p53 on the LPS induced hyperpermeability and he is currently focused on the intracellular cascades which mediate that effect.
Raji Rajesh Lenin, Ph.D
Gangaraju lab, Department of Ophthalmology, University of Tennessee Health Science Centre
Research Focus: Effect of hyperglycemia and TNF-α in ER stress induced tight junction alterations and vascular dysfunction in Human Retinal Endothelial cells. ECIS will be applied to understand the barrier functional changes in endothelial cells during diabetes.
Pathology and Laboratory Medicine, University of Pennsylvania
Research Focus: Investigate the mechanisms underlying hypoxia-driven sarcoma metastasis, as well as the role of ECM in tumor cell extravasation.
ECIS School Graduates (October 2016)
From left to right: Christian Renken - Applied BioPhysics, Randy Strauss - Virginia Tech Carilion Research Institute, Matthew Pennington - Cornell University, Wei-Sheng Chen - National Institute of Allergy and Infectious Diseases (NIAID)
Baker Institute for Animal Health, Cornell University
Research Focus: The Van de Walle lab focuses on the creation of ex vivo model systems to study ocular herpesvirus pathogenesis and for the evaluation of antivirals in a more physiologically relevant setting. We are currently exploring ECIS as a technique to aid in these studies. Additionally, we have utilized ECIS to study various aspects of mesenchymal stem cell biology.
Wei-Sheng Chen, Ph.D.
National Institute of Allergy and Infectious Diseases (NIAID)
Research Focus: As a Postdoctoral Fellow, Dr. Chen is responsible for exploring the biological mechanisms of the systemic capillary leak syndrome (SCLS), an ultra-rare orphan disease that is characterized by acute and severe recurrent attacks associated with a rapid fall in blood pressure. Currently, there is no cure for SCLS and the clinical management is primarily supportive.
Virginia Tech, TBMH Program - Dr. Gourdie Lab
Research Focus: There is a growing appreciation that the gap junction protein, Cx43, has both channel -dependent and -independent functions. Cx43 shares the actin-binding scaffolding protein Zonula Occludens 1 (ZO-1), with both calcium-dependent adhesions junctions and tight junctions. The commonality of ZO-1 raises the prospect of regulatory and functional cross-talk between different classes of intercellular junction. My current goal is to examine the effects of a Cx43 C-terminal mimetic peptide on barrier function.
ECIS School Graduates (June 2016)
From left to right: Doug Chung - UCLA, Kaushali Thakore-Shah - UCLA, Christopher Turner - University of British Columbia, Cameron Oram - University of British Columbia, Chris Barrett - MIT
Doug Chung, Ph.D.
UCLA, The Stein Eye Institute
Research Focus: Affecting approximately 4% - 5% of the world population above the age of 40, the corneal endothelial dystrophies are a group of heritable bilateral disorders that lead to the visual impairment and discomfort through the development of corneal opacities and edema as a result of corneal endothelial cell dysfunction and/or cell loss. We are currently using ECIS to characterize corneal endothelial proliferation, migration, and cell barrier function in cell-based models of corneal endothelial dystrophies.
Kaushali Thakore-Shah, Ph.D.
Research Focus: My research focus is to find ways to improve the proliferation potential of corneal endothelial cells so that they may be used for regenerative cell therapy.
Christopher Turner, Ph.D.
University of British Columbia, Granville Lab, International Collaboration on Repair Discoveries (ICORD)
Research Focus: The Granville lab is focused on researching the role of granzymes in inflammation and disease. Our goal is to expand our current knowledge in granzyme biology and their role in pathogenesis. We also aspire to translate this knowledge to develop novel therapeutic approaches for management of chronic inflammatory disorders in which granzymes are involved.
University of British Columbia
Research Focus: Coming soon
Chris Barrett M.D.
Research Focus: My research focuses on the links between the inflammatory response and coagulation system after major traumatic injury. The goal is to develop early interventions that have both immediate benefits in coagulopathic trauma patients while also having additional protective effects further in the hospital course to prevent late deaths after major trauma (due to organ failure and sepsis).